tag:blogger.com,1999:blog-12657029.post4486055605683587201..comments2023-03-23T09:56:03.136-04:00Comments on Amazed at ignorance: Cortisol and Phosphatidyl serineJohn D. Ayerhttp://www.blogger.com/profile/08662722377040114818noreply@blogger.comBlogger60125tag:blogger.com,1999:blog-12657029.post-44150285020816687402016-08-18T16:46:38.114-04:002016-08-18T16:46:38.114-04:00With Cushing vitamin C cause water retention. I h...With Cushing vitamin C cause water retention. I have Cushing and I take PS and it works well. It good to a balance of vitamin c but for people who have high levels of cortisol it's not good. Anonymoushttps://www.blogger.com/profile/06923404187706228647noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-23541003870409925632016-08-18T16:42:55.804-04:002016-08-18T16:42:55.804-04:00That's not all you have to do more research.. ...That's not all you have to do more research.. That's just a overview. My cortisol levels has be high every since I was 11years old. So it more than just having a stressful job or going to the gym. People cortisol levels can be high for many reasons. It's just not what you read when you google it. Anonymoushttps://www.blogger.com/profile/06923404187706228647noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-92080107017304553312016-08-18T16:36:41.268-04:002016-08-18T16:36:41.268-04:00Vitamin C cause water retention in people with Cus...Vitamin C cause water retention in people with Cushing. There is not cure for it. Eliminating sodium and eating a good balanced diet also the hope of natural supplements like PS helps control the symptoms doctor prescriptions also damages organs and make the situation worse believe you me I know I have Cushing. Anonymoushttps://www.blogger.com/profile/06923404187706228647noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-53624928659407191872016-08-18T16:33:00.479-04:002016-08-18T16:33:00.479-04:00With Cushing vitamin C cause water retention. I h...With Cushing vitamin C cause water retention. I have Cushing and I take PS and it works well. It good to a balance of vitamin c but for people who have high levels of cortisol it's not good. Anonymoushttps://www.blogger.com/profile/06923404187706228647noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-13388073856071612332016-08-18T16:32:58.878-04:002016-08-18T16:32:58.878-04:00With Cushing vitamin C cause water retention. I h...With Cushing vitamin C cause water retention. I have Cushing and I take PS and it works well. It good to a balance of vitamin c but for people who have high levels of cortisol it's not good. Anonymoushttps://www.blogger.com/profile/06923404187706228647noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-62672696297569490782016-07-27T12:52:24.068-04:002016-07-27T12:52:24.068-04:00Yes can someone recommend a manufacturer and dose ...Yes can someone recommend a manufacturer and dose for insomniacs? Or suggest something that works better? I have been taking phosphatidyl serine for a couple of weeks (NOW Foods, 900 mg at bedtime) and continue to have terrible insomnia. I was using Seriphos but the company switched the formula and now the dosage of phosphorylated serine in their formulation is too small. Help! I am sooo sleep deprived.<br />-MelissaAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-12657029.post-61310840878035690922016-07-08T11:49:38.631-04:002016-07-08T11:49:38.631-04:00Hi there,
Similar to one of the other posters, I...Hi there, <br /><br />Similar to one of the other posters, I'm finding it impossible to lose weight, despite a low carb diet that has always worked well for me in the past few years.<br /><br />Age 53, menopausal.<br /><br />My hormone doc suggested PS for my hot flashes that didn't actually seemed hormone related. After researching I find that it's supposed to help with sleep, brain function and wieght loss. Fantastic I thought.<br /><br />I started on one 100mg per day. Took it at night but found I was waking up with headaches. Switched to day use, no headaches.<br /><br />No change in weight or brain fog for about two weeks, so upped it to 300 a day in the morning. Brain function getting better, but no weight difference.<br /><br />Believe me when I say... I know I'm not eating too much. I don't do sugar, grains, but I do protein, healthy fats, berries and vegetables. Low carb since 2009 and working well until this last year. Menopausal for about 5 years, but it's only this last year that nothing seems to work.<br /><br />Looks like the weight works in the first week for most people, yet I'm on week three with no difference. <br /><br />I wonder if it's the brand or dose?<br /><br />Brain function better, which is great.<br /><br />Can anyone suggest a brand that they've had the most success with?<br /><br />Thanks!<br /><br />Lorrainemehttps://www.blogger.com/profile/08670762837686930927noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-591774727801017392016-05-27T04:22:48.587-04:002016-05-27T04:22:48.587-04:00Some people were asking how PS actually works...it...Some people were asking how PS actually works...it works by re-sensitizing the hypothalamus (and other areas of the brain) The hypothalamus is responsible for sensing cortisol in the bloodstream, and then outputting a hormone (CRH) which triggers the pituitary to output another hormone (ACTH) which stimulates the adrenals to release cortisol.<br /><br />The feedback loop can get broken when under severe stress for a long time (physiological, environmental or psychological) which means the hypothalamus cortisol sensors become resistant to cortisol, and the hypothalamus puts out too much CRH.<br /><br />It's a bit like the fuel gauge in your car being broken. The car is telling us we always need more fuel, even if we have a full tank.<br /><br />Also worth mentioning cortisol's action on the body: in periods of stress one of it's jobs is to raise blood sugar levels so we have enough energy for fight or flight.It does this through gluconeogenesis, which is a fancy way to say it creates glucose from fat and muscle. The thing is that it selects peripheral fat to burn (not visceral) - and then with increased bloodsugar, our body stores this excess as fat around the belly and hips. That is why high cortisol leads to the pear-shaped body type.<br /><br />This dance creates a swing between cortisol and insulin as they fight to keep blood sugar balanced, which tires the pancreas, and also leads to moments of low sugar (like during the night) when adrenaline is sometimes released to raise blood sugar - often causing people to wake with a fright during the night, or have vivid and scary dreams.<br /><br />The best way to assess this is the 24h saliva cortisol test. Your cortisol slope (high in the morning, low at night) is said to be more of a risk factor than smoking in chronic disease.Anonymoushttps://www.blogger.com/profile/17489042224160069903noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-90670874467406730132015-10-28T11:36:20.035-04:002015-10-28T11:36:20.035-04:00I have a lot of joint pain anyway, arthritis from ...I have a lot of joint pain anyway, arthritis from hard living :-) I didn't notice any new joint pain. This sounds like it is worth researching, just remember, a blog or a blurb is an anecdote, not a verifiable fact. One must do their own research before they believe anything. John D. Ayerhttps://www.blogger.com/profile/08662722377040114818noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-66689126877206965022015-10-07T14:40:51.048-04:002015-10-07T14:40:51.048-04:00A note to Linda who quit taking PS when she got jo...A note to Linda who quit taking PS when she got joint pain - I have read in a book by Datis Kharrazian called "Why Do I Still Have Thyroid Symptoms?" that you know when you are taking a therapeutic dose of PS when you have some joint pain. In other words, the joint pain was a good sign that the dose was right. I don't know if that goes away after awhile or not.Maryhttps://www.blogger.com/profile/12872579269971326449noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-12728834967956315552015-03-11T20:09:17.067-04:002015-03-11T20:09:17.067-04:00No, I really don't. My expertise is actually ...No, I really don't. My expertise is actually in advanced manufacturing and I have been studying anthropology and sociology for many years. I'm no expert in biology or nutrition. I know a little, but, I can't give advice.<br /><br />Sorry it took so long to publish your comment, I've had a full schedule lately.John D. Ayerhttps://www.blogger.com/profile/08662722377040114818noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-59648883060583501612015-01-02T20:17:04.843-05:002015-01-02T20:17:04.843-05:00Do you know how PS reduces cortisol? Does it preve...Do you know how PS reduces cortisol? Does it prevent you from making so much, or does it stop your body from using some of what it makes? Or something else?<br /><br />I am trying to find out if it is safe for people with Addisons disease to take. Addisons is an autoimmune disease where your body can't make cortisol and you have to take steroid replacements.<br /><br />I got two free samples and tried them for ADHD symptoms. It worked great! I could focus and my appetite was reduced as well. However, I didn't know it messed with cortisol until I did some more in-depth research before deciding to buy a bottle.<br /><br />If it only prevents the body from making some cortisol, it should be fine for me because my body doesn't make any cortisol to block anyway. However, if it stops the body from using some cortisol/replacements then I could be in trouble after a few days. I didn't have any Addisons symptoms for the days I took it.<br /><br />I really want to be able to take this supplement. Thanks for any help you can give me. :)Emilyhttps://www.blogger.com/profile/15494934350698240311noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-70793600480126984562014-02-01T10:10:42.672-05:002014-02-01T10:10:42.672-05:00This increased cortisol can also be very much caus...This increased cortisol can also be very much caused by metal poisoning, mercury toxicity or sensitivity which I have from mercury amalgam and vaccines. The mercury poisons the endocrine system and destroys enzymes, ruins antioxidant pathways and especially glutathione, Vit C and E redox. This poisons the hypothalamus, the pituitary, the thyroid, pineal gland. I have just had 18 amalgams removed and am trying to regain control over my endocrine system. hypothalamic obesity is probably what most Americans are suffering from and the FDA approved mercury poisoning the root.Unknownhttps://www.blogger.com/profile/01193805686999961204noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-5494524318986378132013-08-28T13:50:14.000-04:002013-08-28T13:50:14.000-04:00John, Arnold -
Yes, PS is derived from soy. I am ...John, Arnold -<br /><br />Yes, PS is derived from soy. I am not sure about direct substitutes, but I believe many of the same benefits can be captured with any kind of protein supplementation, so long as it is a complete protein. Don't quote me on that, but that is my understanding.RP Longhttps://www.blogger.com/profile/15028013805248797978noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-22949919295078793232013-08-28T13:45:50.136-04:002013-08-28T13:45:50.136-04:00I don't know how the PS was derived.I don't know how the PS was derived.John D. Ayerhttps://www.blogger.com/profile/08662722377040114818noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-88057264644746776052013-08-01T16:30:18.032-04:002013-08-01T16:30:18.032-04:00John, I read this amazing blog, I have a question:...John, I read this amazing blog, I have a question: Does it this phosphatidylserine be made of soy? Do you know if there is an alternative? I read somewhere about the cabbage alternative, since I cannot use soy, because it does increase Estrogen levels (and so also lets you gain wight) and I am trying to keep my estrogen at bay. Any advise on any brand that uses some other ingredient than Soy? thank youArnoldhttps://www.blogger.com/profile/14453364138755611652noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-45915357892840490672013-05-18T14:33:20.840-04:002013-05-18T14:33:20.840-04:00Hi,
I just stumbled on this website because I was...Hi,<br /><br />I just stumbled on this website because I was searching for information on PS. I'm type 1 diabetic, and I was reading about the relationship between human growth hormone, blood glucose, cortisol, etc.<br /><br />What you describe about your evening/morning blood sugar readings reads exactly true for me, too. I am not overweight, but I am fighting to control my BG despite ever-increasing insulin doses.<br /><br />On the strength of your experience, I'm going to give PS a try. All the clinical research I can find seems to suggest that it's not harmful, so at the very least I would be taking a placebo.<br /><br />Are you still taking it?<br /><br />Thanks for the info!<br /><br />Ryan<br />RP Longhttps://www.blogger.com/profile/15028013805248797978noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-75211125449799440652013-03-27T10:56:25.447-04:002013-03-27T10:56:25.447-04:00Found this blog right before clocking into work,as...Found this blog right before clocking into work,as I had just purchased phosphatidylserine powder to make my own supplement capsules. in 2010,I reached my highest weight of 257lbs. Being 27, I was angry at myself for letting it get that bad! I started dieting & exercising,but the weight would either go up or be stuck. I always maintained 150-160lbs,so being 100lbs heavier was a huge shock. I literally gained 10-20lbs per year. <br /><br />I went to doctors & dieticians who all told me the same thing, stop eating so much. I have IBS and a number of food sensitivities. So my intake is already restricted. I thought I wasn't exercising enough so I pushed further. No help.<br /><br /> I also have Generalized Anxiety Disorder,and a stressful job. I started getting a "buffalo hump" on the back of my neck in addition to the fast weight gain. so I did research on cortisol,and decided to try PS. <br /><br />Given my pre-existing conditions and how overweight I was,I took really high doses,900mg/day. <br /><br />Like clockwork,I was finally losing the 1-2lbs per week that my diet/exercise regimen was supposed to be doing for me. I was able to work out longer,recover easier etc. It's not a miracle pill,it just made my body feel somewhat normal again. <br /><br />It's taken 3 years and then some to drop down to 200lbs. I plan to lessen the dosages the closer I get to my goal. Npt saying this is for everyone, it's just what worked for me.Unknownhttps://www.blogger.com/profile/06624900139078595332noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-4008642696660979332013-02-06T11:39:41.736-05:002013-02-06T11:39:41.736-05:00Melanie said.....
John thank you for the article ...Melanie said.....<br /><br />John thank you for the article it's very informative. I too like to do my research on things like this, I had researched the supplement and started taking it about 1 week or two ago. <br /><br />I'm 41 years old 5'7 1/2" and 145 lbs (currently 140). My friends look at me like I’m crazy when I tell them that I want to lose weight! About 6 years ago I weighed 175lbs. I was fed up and decided to go on a diet which included running 4 days a week. Within 9 months I had gotten down to 138lbs and within a year or two I reached 133, which I was very comfortable with. <br /><br />During the 2012 holiday season I had gone from 138 to 145lbs and I was disgusted. I put myself on a strict diet using the "lose it" app to track my food intake along with my exercise data. I calculated my BMR and came up with the applicable daily calorie intake in order to lose 2lbs a week; it allowed around 950-980 calories a day, before adding my exercise in. So I’ve been eating about 1300 calories and working out 6 days a week (3 days of running and 3 days of cross training (TRX). I'm a single mom of 2 children so I’m always on the run! I've been sticking to the diet and workouts and I had only lost 3 lbs. in 4 weeks. I started taking PS and within days I already lost 1-2 lbs. for a total of 5.1 lbs. weight loss for the 5 weeks. Everyone kept telling me that I’m not eating enough calories and that's why I wasn't losing, I’m sorry doesn't make sense, decrease calories and lose weight, bottom line! Anyway, I will be taking the PS until I reach my goal of 133 (7 more lbs.). I will try and remember to post my results but I wanted to let everyone know that if they do their research they will find that it can be a very effective supplement to help to reduce fat (which was my issue). <br /><br />As far as the other symptoms of high Cortisol levels; trouble sleeping, concentrating, memory etc… I find it a little helpful with the sleep, especially since I exercise from 5:30-7 pm so I’m a little charged up at night and I do feel a little calmer. I can tell you I certainly have ADHD with a BIG emphasis on the H (hyper). <br /><br />I’m currently taking 100mg 3 times a day. <br /><br />Thanks again for confirming what my research had found and your wonderful blog! <br /><br />Best luck with your success! <br />Anonymousnoreply@blogger.comtag:blogger.com,1999:blog-12657029.post-85506062474667888112012-11-26T20:38:37.059-05:002012-11-26T20:38:37.059-05:00Thanks Monroe444: I almost deleted your comment b...Thanks Monroe444: I almost deleted your comment because the coupon code makes it look like spam, but, I figured even if you are shilling you make a good point about GMO soy. It is pretty hard to keep GMO products out of the mix because of cross pollination, so I am not sure I trust labels that advertise "NO GMO". Still, if the prices are lower the idea of No GMO is good so it can't hurt to check prices.John D. Ayerhttps://www.blogger.com/profile/08662722377040114818noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-84660154889116790812012-10-03T16:30:40.807-04:002012-10-03T16:30:40.807-04:00I really admire people who do their homework.
Act...I really admire people who do their homework.<br /><br />Actually people do "burn bone". This is especially harmful in women where it is called osteo (meaning bone) perosis. The body requires calcium to process protein. If the body is eating muscle instead of fat the body will extract the calcium necessary to digest protein from bones.<br /><br />I was talking to my dental hygienist once and she was doing body building with a trainer and eating a high protein diet. I asked her what she was doing about calcium and she said nothing, her trainer had told her it would clog her arteries. Here is a woman in her 30's digesting protein on a low calcium diet. I told her to go read up on how protein is digested. She sued her trainer.<br /><br />People, do your homework, preferably before you post dumb sh*t. My blogs are anecdotal references which should encourage you to study and learn. Unless, like the poster directly above someone already knows everything.John D. Ayerhttps://www.blogger.com/profile/08662722377040114818noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-85468934954047092892012-10-02T12:07:59.525-04:002012-10-02T12:07:59.525-04:00"gain weight and burn....bone" bone? are..."gain weight and burn....bone" bone? are you kidding me? hahahAnonymousnoreply@blogger.comtag:blogger.com,1999:blog-12657029.post-6277523847534082192012-09-19T01:54:17.131-04:002012-09-19T01:54:17.131-04:00Cortisol and metals:
http://www.ncbi.nlm.nih.gov/...Cortisol and metals:<br /><br />http://www.ncbi.nlm.nih.gov/pubmed/18221981<br /><br />John D. Ayerhttps://www.blogger.com/profile/08662722377040114818noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-66064872071528366702012-09-10T12:52:18.153-04:002012-09-10T12:52:18.153-04:00Thanks Elizabeth! That is great information. I w...Thanks Elizabeth! That is great information. I was not able to find a study directly linking thimerosal to cortisol, but, in my case that idea sounds reasonable. As a child I had a bad habit of biting thermometers. I never meant to, I just did. I eventually refused to have my temperature taken. Even today I sometimes bite down without realizing it when I am using an oral thermometer. On top of that I am a big sea food fan. I think I will ask that my blood mercury level tested.<br /><br />I am currently using L-Arginine as a cortisol reducing agent. I stopped taking PS two months ago and I have lost ten pounds in the last two months since starting L-Arginine.<br /><br />I have been doing timed sudokos and logic puzzles as a way to gage my mental abilities and I have noticed that on PS my evening and morning scores were lower than mid day. With L-Arginine my scores are consistent.<br /><br />I am going to use L-Arginine alone for 6 months and then include PS and L-Arginine together for 6 months. I will watch my puzzle times and weight to see how things go.John D. Ayerhttps://www.blogger.com/profile/08662722377040114818noreply@blogger.comtag:blogger.com,1999:blog-12657029.post-67976838605103218192012-09-10T04:33:28.744-04:002012-09-10T04:33:28.744-04:00And I forgot to mention, a Hep B shot with thimero...And I forgot to mention, a Hep B shot with thimerosal (yes mercury) and ten days later, clinical MS. It was the dental amalgams but the Hep shot pushed me beyond what my brain could take.<br /><br />Everyone...if you get vaccinations...get them thimerosal free.<br />-Elizabeth.Anonymousnoreply@blogger.com